Multiphysics Simulation Group
Department of Mechanical Engineering, IIT Kharagpur

Welcome to Multiphysics Simulation Group

Welcome to the Multiphysics Simulation Group at IIT Kharagpur. Our research operates at the intersection of numerical methods, applied mechanics, thermodynamics and bioprocess engineering. We specialize in developing high-fidelity numerical frameworks to understand complex phenomena, with a particular interest in applications such as delivery systems for next-generation therapeutics and hydrodynamic cavitation. Our mission is to bridge fundamental physics with scalable engineering solutions to address challenges in healthcare, advanced manufacturing and energy.

News

Apr 2026
Our paper on "Simulating surfactant effects in phase-transforming fluids" in collaboration with Gomez Lab, where SM contributed through conceptualization, problem formulation and writing, is accepted for publication in Physics of Fluids. DOI Link
Apr 2026
Our paper on "Understanding Size Distributions During Lipid Nanoparticle Manufacturing Through Mechanistic Modeling" is accepted for publication in ACS Omega.
Mar 2026
Saikat Mukherjee joins as an Assistant Professor in the Department of Mechanical Engineering at IIT Kharagpur.

Lab Members

Principal Investigator

SM
Saikat Mukherjee
I am an Assistant Professor in the Department of Mechanical Engineering at IIT Kharagpur since March 2026, where I lead the Multiphysics Simulation Group. Before joining IIT Kharagpur, I worked as a Process Systems Engineer at Biocurie Inc. for 6 months. Prior to that, I was a postdoc in Braatz Group at MIT, where I worked on understanding and numerically simulating self assembly of lipids while manufacturing mRNA based vaccines. I got my PhD from Gomez Lab at Purdue University, where I worked on phase field models for cavitation modeling. I completed my B.Tech. from IIT Roorkee in 2016. Broadly, my areas of interest include applied mechanics and scientific computing.

Publications

  1. JCP2025
    Hydrodynamic cavitation with non-condensable gases: A thickened interface method with differentiable non-equilibrium thermodynamics based on van der Waals theory
    Mukherjee, S. and Gomez,H.
    2025 Journal of Computational Physics, p.114070. DOI Link
  2. BTAdvances2025
    Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics
    Inguva, P.K., Mukherjee, S., Walker, P.J., Tenberg, V., Devos, C., Shin, S., Wu, Y., Santra, S., Wang, J., Singh, S., Kanso, M.A., Kim, S.H., Trout, B.L., Bazant, M.Z., Myerson, A.S. and Braatz, R.D.
    2025 Biotechnology Advances, p.108643. DOI Link
  3. AIChe2025
    Impinging jet mixers: A review of their mixing characteristics, performance considerations, and applications
    Devos, C., Mukherjee, S., Inguva, P., Singh, S., Wei, Y., Mondal, S., Yu, H., Barbastathis, G., Stelzer, T., Braatz, R.D. and Myerson, A.S.
    2025 AIChE Journal, 71(1), p.e18595. DOI Link
  4. CAndF2024
    Mixtures of phase transforming fluids and gases: Phase field model and stabilized isogeometric discretization
    Mukherjee, S. and Gomez, H.
    2024 Computers and Fluids, p.106176. DOI Link
  5. PFM2023
    Phase-Field Modeling for Flow Simulation
    Gomez, H., Leng, Y., Hu, T., Mukherjee, S. and Calo, V.
    2023 In Frontiers in Computational Fluid-Structure Interaction and Flow Simulation: Research from Lead Investigators Under Forty 2023 (pp. 79-117). Cham: Springer International Publishing. DOI Link
  6. CMAME2023
    Stabilized formulation for phase-transforming flows with special emphasis on cavitation inception
    Mukherjee, S. and Gomez, H.
    2023 Computer Methods in Applied Mechanics and Engineering, 415, p.116228. DOI Link
  7. POF2022
    Effect of dissolved gas on the tensile strength of water
    Mukherjee, S. and Gomez, H.
    2022 Physics of Fluids, 34(12), p.126112. DOI Link
  8. APL2020
    Understanding how non-condensable gases modify cavitation mass transfer through the van der Waals theory of capillarity
    Mukherjee, S. and Gomez, H.
    2020 Applied Physics Letters, 117(20), p.204102. DOI Link
  9. APL2019
    Flow and mixing dynamics of phase-transforming multicomponent fluids
    Mukherjee, S. and Gomez, H.
    2019 Applied Physics Letters,115(10), p.104101. DOI Link
  10. JHT2018
    Molecular Dynamic Study of Boiling Heat Transfer Over Structured Surfaces
    Mukherjee, S., Datta, S. and Kumar Das, A.
    2018 Journal of Heat Transfer, 140(5). DOI Link
  1. Mixing within Confined Impinging Jet Mixers: Innovations in Monitoring for Novel Applications
    Devos, C., Wei, Y., Mukherjee, S., Mondal, S., Barbastathis, G., Stelzer, T., Braatz, R. and Myerson, A.S.
    2024 In 2024 AIChE Annual Meeting. AIChE.
  2. Mechanistic Modeling Strategies for Lipid Nanoparticle Production
    Inguva, P., Mukherjee, S., Walker, P., Kanso, M., Wang, J., Wu, Y., Tenberg, V., Santra, S., Singh, S., Myerson, A. and Braatz, R.
    2024 In 2024 AIChE Annual Meeting. AIChE.
  3. Understanding cavitation mass transfer at different scales
    Mukherjee, S. and Gomez, H..
    2021 In APS Division of Fluid Dynamics Meeting Abstracts (pp.N01-053).
  4. How Non Condensable gases modify phase change mass transfer
    Mukherjee, S. and Gomez, H..
    2020 APS Division of Fluid Dynamics Meeting Abstracts, J11.00009.
  5. Flow and mixing dynamics of phase transforming multicomponent fluids
    Gomez, H. and Mukherjee, S..
    2019 APS Division of Fluid Dynamics Meeting Abstracts, S23.002.
  6. Development of Molecular Microscope for Boiling Heat Transfer: A Numerical Study
    Mukherjee S., Datta S. and Das A.K.
    2016 6th International and 43rd National Conference of Fluid Mechanics and Fluid Power, Allahabad, December 15-17, 2016.

Join Our Lab

PhD Positions

We are actively seeking PhD applicants to join our research group and contribute. Prospective students should first explore our website and publications to identify specific themes that align with their long-term academic goals. Once you have identified a potential area of focus, please send an introductory email to saikat@mech.iitkgp.ac.in with the subject line “PhD Application – [Your Name] – [Specific Research Topic].” In your email, please provide a concise summary of your research background and attach a CV in PDF format. Please note that the Department of Mechanical Engineering at IIT Kharagpur accepts rolling applications for PhD positions throughout the year, allowing highly motivated candidates to apply at any time.

Others

We are always looking for motivated students to join our research efforts and contribute to our ongoing projects. If you are interested in working with us, please begin by exploring our website to identify 1–2 specific topics that align with your academic interests and career goals. Once you have a clear idea of which areas excite you most, please send an email to saikat@mech.iitkgp.ac.in with the subject line "Research Inquiry: [UG/Master's/Postdoc] – [Your Name]." In your message, provide a brief introduction including your major and current year of study, and explain why the specific topics you identified are a good fit for your skills and interests. Please ensure you attach a current copy of your CV in PDF format so we can better understand your background. We review inquiries on a rolling basis and look forward to hearing how you can contribute to our lab’s mission.